The Food and Drug Administration has cleared Geron, a stem cell company based in Menlo Park, CA, to move forward with clinical tests of its experimental cell therapy for spinal cord injury, which is derived from embryonic stem cells. The company, which has been working on cell based therapies for the last decade, first won permission to begin clinical testing in January of 2009. But the trials were put on hold last August due to new safety concerns from animal tests. The clinical trial marks the first human tests of a therapy derived from embryonic stem cells.

The cell therapy, called GRNOPC1, is made by transforming embryonic stem cells into oligodendrocytes--a type of brain cell that wraps itself around neurons, forming a fatty insulation layer that allows electrical messages to be conducted throughout the nervous system. In many spinal-cord injuries, these cells are damaged, but the underlying nerve cells remain intact. The new cells are then injected into the site of the injury, coating exposed nerves and restoring communication to the nervous system.

As I noted in a previous post:

Scientists published the results of a successful study testing the therapy in animals in 2005, showing that paralyzed rats injected with the cells were able to walk again. Since then, Geron has been conducting numerous studies intended to show the safety of the cell-based therapy, as well as developing production methods that would make the cells as easy to use as more traditional treatments. Geron researchers have also developed a way to reliably freeze and thaw brain cells, so that they can be manufactured in a central location, and then shipped to the hospitals where they will be used.

According to a statement from Geron:

The clinical hold was placed following results from a single preclinical animal study in which Geron observed a higher frequency of small cysts within the injury site in the spinal cord of animals injected with GRNOPC1 than had previously been noted in numerous foregoing studies. In response to those results, Geron developed new markers and assays as additional release specifications for GRNOPC1. The company completed an additional confirmatory preclinical animal study to test the new markers and assays, and subsequently submitted a request to the FDA for the clinical hold to be lifted.

Advanced Cell Technology, a stem cell company based in Marlborough, MA, hopes to follow Geron. The company announced this week that it has submitted new materials to the FDA in regards to its application, first filed in November, to begin clinical trials of a cell therapy for patients with Stargardt's Macular Dystrophy, an inherited eye disease.

Searching for a hot news topic or buzzword can already lead an unsuspecting person to harmful malware. Recent articles are full of warnings about malware hidden in links that are supposedly about the World Cup or the Icelandic Volcano. Estimates have suggested that about 14 percent of traditional searches for trending news go to sites hosting malware.

As real-time search becomes more important, the problem of malware-related results could become much worse, according to a talk given yesterday by Dan Hubbard, CTO of Websense, at the Cloud Security Alliance Summit, which took place at the Black Hat security conference in Las Vegas. The event brought together speakers from government, industry, academia, and the underground. Hubbard outlined several ways that real-time search results are easy to poison.

Much of the problem stems from the nature of information provided in real time, Hubbard says. It's noisy, spammy, and not authoritative. So search engines have a difficult task ahead determining what links can be trusted.

The results are also easy to manipulate. Hubbard experimented with searches related to the recent Boston marathon. He found that he could get posts to the top of real-time search engine results by posting in anticipation of events. For example, he posted information about who had won before there was a winner, garnering a top spot on real-time results pages. He found that he could trick even Google by introducing typos that other users might be likely to make (such as "Botson" marathon). And, by posting images along with text, Hubbard found that he was able to rocket his posts to the top of results pages.

Hubbard says spammers could use social graphs to manipulate real-time search results as well. A botnet, for example, could create large numbers of interconnected Twitter accounts, creating a source of information that could seem authoritative. Hubbard also pointed to recent reports of spammers taking over the Twitter accounts of well-known users.

There may be big opportunities for spammers as location gets factored into the ranking of real-time results. Current location services trust where users say they are, he says. Location is also relatively easy to spoof. Spammers could add their links to real-time search ranks by seeming, for example, to tweet about the Icelandic volcano from Iceland, or about the Boston marathon from the finish line.

Hubbard plans to continue his investigation by looking at how spammers might be able to influence Facebook streams and search, and what they might be able to do with the popular location-based social network Foursquare.

Yesterday at the Plug In conference in San Jose, CA, technology company Ecotality and design firm Frog Design announced a new line of electric-vehicle chargers. The chargers, which will be rolled out in demonstration projects in 16 states with funding from the US Department of Energy, have a color touchscreen and are connected to the internet. A user can program the chargers to charge a vehicle by a certain time and when prices reach a certain level; the connectivity will also allow utilities to display messages and provide data to the charger about fluctuating electricity prices.

With its black and white color scheme and rounded edges, the Blink looks like it was designed by Apple. The cord-winding station below the touchscreen even resembles the clickwheel of a classic iPod. (Not surprising, since Frog famously created the look or "design language," called Snow White, used by Apple for its computers from 1984 to 1990.) Frog representatives explained that the chargers are meant to look friendly and approachable. They're also ready for co-branding--Starbucks or Best Buy might offer a free charge in their parking lot to get electric vehicle owners to spend money there, and could add their logo to the Blink on a skin. The company will offer a wall-mounted residential version and a free-standing version designed for parking lots.

Lee Slezak, a representative of the US Department of Energy vehicle technology program, and conference attendee, said Blink offers capabilities other chargers lack. "One thing we've been pushing for as we roll out charging infrastructure is to make sure it has the smallest possible impact on the grid."

Enabling communication between the utilities and the consumer, as the blink does, will help both: the utility can offer lower rates when demand is lower and users can program the charger to take advantage of this.

This video shows how the Blink system works: